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Hi Zigan - Please bear in mind when posting here, that you are posting to a forum - not to an individual person. Please also try to make your questions as specific as possible. We only have very capacity to provide support, so we cannot take on broad questions about how to design overall studies.
On your questions:
>>Can I use the IBC in YRD for my research?
No, it is only valid for national-scale modeling. See
this page for more info.
>>How can I set the LEAP to contain the four provinces in a LEAP model?
Use the General: Regions screen to establish multiple regions in your model. Suggest you start by reading this.
>> Optimization works similarly for any scale and similarly for both single and multi-region models. Suggest you start by reading this.
I hope this helps and thanks for your understanding!
Charlie